Platelet-Rich Plasma (PRP)

ABC News Report on the benefits of Platelet-Rich Plasma (PRP)

What is PRP?

Our research team has confirmed that neurogenic growth factors have a regenerative effect on peripheral nerves that are adversely affected by co-morbidities such as diabetes and HIV. Neurogenic growth factors found in Accelerate GF have a profound effect on the clinical presentation seen in patients suffering from HIV as well as Diabetes associated peripheral neuropathy.  Improved sensory perception, proprioception as well as decreased pain are expected clinical outcomes.

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Platelet-rich plasma fibrin matrix when combined with collagen has been found to provide a micro-scaffold infrastructure to augment angiogenesis, epithelialization and subsequent wound healing. Acting as a slow-release form of essential growth factors, Accelerate GF can be used for wound optimization. All patients should be screened for adequate vasculature, anemia as well as hypoalbuminemia.

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Platelet-rich plasma contains a variety of growth factors that are essential in the healing process of injured or damaged tissue.  Accelerate GF  is a mixture of platelet-rich as well as platelet-poor plasma which contains a high concentration of growth factors as well as fibrin which is essential in wound healing. The platelets in Accelerate GF  are aggregated then activated in a proprietary way to amplify the release of growth factors. This product is indicated for mild to moderate osteoarthritis as well as an array of tendinopathies.  Additionally, Accelerate GF  is indicated for chronic non-healing wounds and is used as a wound optimizer when administered in a peri-wound fashion. Angiogenic as well as epithelial growth factors are responsible for rapid wound closure.

Frequently Asked Questions

What is Accelerate GF™?

Accelerate GF™ is a “high concentration”, Growth Factor product which can be used in conjunction with your Stem Cell treatments, or as a Stand-Alone Regenerative Therapy in Seattle, exclusively at Pinnacle Integrative Health for the effective treatment of musculoskeletal injuries and conditions, neuropathy and chronic non-healing wounds.  Accelerate GF is a proprietary activator/aggregator formulation developed by Plasma Solutions specifically for deriving an injectable platelet concentrate with a high concentration of both platelet-rich plasma and platelet-poor plasma, and activators of Growth Factors (GF), recruiters of Stem Cells (SC), proteins and fibrinogen in high concentrations. These all work together to facilitate the healing of soft tissue, tendons, ligaments, muscles and joints, and nerves.

Accelerate GF has an overall higher growth factor concentration and liquid-fibrin matrix, the key benefit of which is to promote accelerated proliferation of growth factors for more effective and rapid healing, without the pain experienced on injection with PRP.  It is a natural platelet concentrate used in regenerative medicine that requires only a small amount of the patient’s own blood to initiate the healing process, and is a fast-acting and highly effective way to non-operatively treat certain injury to soft tissue, tendons, ligaments, muscles and joints, and nerves.

How does Accelerate GF  benefit our patients in Seattle?  

Accelerate GF can be used as stand-alone treatment or in conjunction with stem cell therapy to treat patients suffering from (i) musculoskeletal injury, (ii) neuropathy, or (iii) chronic nom-healing wounds, who are seeking  regenerative therapy as an alternative to surgery or drugs, or a complementary treatment to allopathic medicine approaches.  It is a natural, non-operative healing modality that is non-painful, rapid, safe, and results in effective treatment outcomes. Accelerate GF requires only a small amount of a patient’s own blood to stimulate tissue repair, regeneration, and rapid healing without risk of rejection or allergic reaction, disease transmission or infection.

For example, Accelerate GF can benefit patients needing an aggressive healing program in order to avoid surgery (i.e., total knee or total hip replacement) or amputation of a non-healing wound.  It can also be used a pre-stem cell injection to start inflammation and native healing, and form a matrix for stem cells to adhere, with stem cells subsequently being introduced 2 weeks thereafter.  It likewise can be used post-stem cell therapy to “boost” stem cell activity 1-2 months after stem-cell treatment.  The end results are overall better outcomes for patients, increased patient satisfaction and compliance.

What makes Accelerate GF unique relative to standard PRP therapy?

Accelerate GF is our newest regenerative medicine product and is not another PRP product.  Many different products and methodologies exist to prepare PRP, all of which are not equal.  Accelerate GF is not the standard PRP product because it formulates a platelet concentrate that is a combination of both platelet-rich and platelet-poor plasma (PPP), mixed with other key growth factors.  While most companies discard the platelet-poor plasma, Plasma Solutions has found that the PPP actually contains high levels of protein and fibrinogen.  Both are absolutely essential in the wound and injury healing process.  Without fibrinogen it is very difficult for tissue to heal.  As a result, Accelerate GF can be used to treat orthopedic conditions and injuries, as well as peripheral neuropathy, including patients who suffer from diabetic nerve pain.

Accelerate GF both activates and aggregates platelets prior to injection using a proprietary solution.  This is key in promoting rapid healing with minimal to no pain, and is harmless to the patient because it consists of two chemicals that are naturally found in the blood stream.  Most patients actually do feel a difference right away.  Patients also experience little to no pain upon injection, unlike the intense pain patients complain of with standard PRP, and generally do not need to be administered anti-inflammatory medications.  As a result, they are more compliant in completing the full treatment regimen.  Accelerate GF was developed in an actual medical practice, where our team of physicians and technologists were able to see results and optimize product efficacy.

What is the science behind why Accelerate GF works?

Human blood is made up of 93% red blood cells, 6% white blood cells, 1% platelets and plasma.   Platelets are the body’s natural response to injury healing, and in conjunction with the liquid plasma in PRP and PPP contain high concentrations of growth factors that induce accelerated tissue regeneration and proliferation.  When platelets become activated and are injected into damaged tissues, growth factors are released and initiate the body’s natural healing response, including attracting stem cells to the injury.  These blood-borne stem cells, called pluripotent stem cells, have the ability to create new tissue at the injury site.  We have identified 7 growth factors which are released with Accelerate GF.

To maximize the healing process, the platelets must be concentrated and separated from the red blood cells.  In the proper concentration and use, platelets can lower pain level, work extremely fast, and are a complete treatment.   As a regenerative medicine product, the function of Accelerate GF is to maximize the number of platelets and minimize the number of red blood cells in a solution injected into the injured or pained area(s) in order to create, stimulate, and accelerate the body’s natural healing process.  Clinical trials prove the effectiveness and safety of PRP for almost all types of chronic healing, using the patient’s own blood and centrifuging it to create a concentrated platelet solution injected into the injury site.  This has been proven to stimulate tissue repair, regeneration, and rapid healing without risk of rejection or allergic reaction, disease transmission or infection.

What is your activation/aggregation solution?

Plasma Solutions uses a proprietary solution, which is patent pending.  An independent chemical analysis has concluded that it is “safe and effective” when used as an activator/aggregator.  The components of thesolution are actually present in everyone’s blood stream. Accelerate GF does not require refrigeration, and has a long product shelf life of 12 months.

Do you have studies or clinical data to support your product?

There is one published study in the Journal of Treatment and Management of HIV (2013) which actually focuses on our product.  However, there are hundreds of studies and reports that prove the clinical efficacy of PRP and Platelet Concentrates.  These studies and reports date back over 30 years.  By no means is this “new technology”.  You will find several links on our website.

Is your product FDA approved ?

The FDA presently only approves the centrifuge used to produce PRP.  However, all of the components of our kit are individually approved at the manufacturer level.

How long does the treatment take?

After the patient’s blood is drawn, processing time is only 15 minutes.  You should be able to complete your patient’s visit in 30 minutes. We recommend that the patient have 2 to 3 treatments over 4 to 8 weeks to ensure comprehensive healing has been achieved.

How Do I prepare for my Accelerate GF Regenerative Therapy?

  • Drink 1/2 your body weight in ounces of purified water per day two days prior to your scheduled procedure in order to increase blood volume for optimal PRP extraction for best results of your treatment. i.e. if you weigh 150 lbs drink 75oz of water daily.
  • Avoid all non-medication diuretics: coffee, caffeine pills, caffeinated teas for 24 hours prior to the treatment.
  • No sugar, no soda, no gatorade – drink water and non-caffeinated herbal teas.
  • No alcoholic beverages for 48 hours prior to the injection.

These steps are important to achieving the most optimal outcomes for PRP.

Please ask for clarification if necessary.

To schedule a consultation to see if you qualify for Accelerate GF – PRP therapy please  Contact us at: (206) 624-0397

info@pinnacleintegrativehealth.com